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CENTAMIN FORTE syrup

5250 Ft

It naturally promotes the joint’s health, prevents the joint’s degeneration, vitalizes and reinforces connective tissue, specially tendons, articular cartilage. Hereby it replaces the mobility of joints.

It provides an analgesic and anti-inflammatory effect in arthritis, arthrosis, and osteomyelitis. It decreases the pain and inflammation and decreases the stiffness of the joints more effectively than conventional non-steroid remedies.

Data of treatment of pregnant animals are not available, no restrictions known during lactation.  Side effects are unknown

Dosage and administration: Dog: ≤ 10kg: 3 x 1,5ml; 10-20kg: 3 x 3,5ml; 20-30kg: 3 x 5ml; ≥30kg: 3 x 7-10ml; Cat: 0,5 ml/kg; Orally or mixed with feed, in the recommended dose.

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Description

Each 10 ml contains:

Active substances:

Extracts of:

Centella asiatica150 mg
Curcuma longa150 mg
Boswellia serrata150 mg
Syrup baseQ.S.

Other ingredients

Color: Carmoisine (EC 222-657-4)

Preservatives: Sodium-methylparaben and Sodium-propylparaben

Flavor: Blackcurrant

 

Pharmacological and Clinical action: Following the oral administration of a single dose. about 50% is absorbed from the G.I. tract, and plasma peak levels can be observed after four hours. Metabolism starts with the formation of glucuronyl / sulfuronyl conjugates which are recovered from the bile. Asiaticoside is hydrolyzed to Asiatic acid by the intestinal flora. Conjugated triterpenic acids undergo enterohepatic circulation and are recovered in the feces as unchanged Asiatic acid, probably due to the hydrolysis of the conjugate by the intestinal flora. Almost total elimination occurs in 72 hours via feces and about 2% is eliminated via urine.

Centella asiatica: It reduces vascular permeability by enhancing the integrity of vascular endothelial cells and improves microcirculation. Asiaticoside is also known to improve mucopolysaccharide metabolism and improve Glycosaminoglycans synthesis especially that of Hyaluronic acid and chondroitin.

Curcuminoids are extracts derived from the rhizomes of Curcuma longa. The major biological property of curcuminoids is their anti-inflammatory activity, comparable in strength to steroidal drugs and non-steroidal drugs like indomethacin and phenylbutazone.

Curcuminoids are known to have displayed topoisomerase 1 and 2 enzyme inhibition activity. Curcuminoids inhibit enzymes which participate in the synthesis of inflammatory substances in the body and are derived from arachidonic acid like prostaglandins and prostacyclines. The overall anti-inflammatory action of Curcuminoids is also related to their well-known antioxidant properties.

The anti-inflammatory properties of Curcuminoids were tested in a double-blind clinical trial in arthritis 6, and the therapeutic effects were proven to be as effective as phenylbutazone.

Curcuminoids have been shown to inhibit lipid peroxidation, a phenomenon associated with antioxidant as well as anti-inflammatory activities.

Boswellia serrata: The extract of Boswellia serrata inhibits the leukotriene biosynthesis in neutrophilic granulocytes by a non-redox, non-competitive inhibition of 5-lipoxygenase. The effect is triggered by Boswellic acids that bind to the enzyme.

 

Register number: 1697/1/NM/2020 NÉBIH ÁTI (200 ml)

 

  1. Montecchio GP. et al: Centella Asiatica Triterpenic Farction (CATTF) Reducing the Number of Circulating Endothelial Cells in Subjects with Postphlebitic Syndrome. 1991;76(3);256-9
  2. Cesarone MR. et al: Attivita Microcirculatoria della Centella Asiatica nell’Insufficienza Venosa. Minerva cardioangiol. 1994; 42(6) 299-304. (in italian, with english summary)
  3. Srimal, R.C., Dhawan, BN: Pharmacology of Deiferuloyl Methane (curcumin), a Non-Steroidal Anti-Inflammatory Agent. Pharm.Pharmacol. 1973; 25: 447-52.
  4. Ghatak, N., Basu, N: Sodium Curcuminate as an Effective Anti-Inflammatory Agent. Indian J. Exp. Biol. 1974; 10: 235. (short communication)
  5. Srimal, R.C., Dhawan, B.N: Pharmacological and clinical studies on Curcuma longa. 131-42
  6. Deodhar, S.D. et al: Preliminary Study on Antireumatic Activity of Curcumin (Deiferuloyl Methane). Indian J. Med. Res. 1980; 71: 632-634.
  7. Huang, M.T. et al: Inhibitory Effects of Curcumin on in vitro Lipoxygenase and Cyclooxygenase Activities in Mouse Epidermis. Cancer Res. 1991,51,813-9.
  8. Rao, C.V. et al: Inhibition by Dietary Curcumin of Azoxymethane-Induced Ornithine Decarboxylase, Tyrosine Protein Kinase Arachidonic Acid Metabolism and Aberrant Crypt Formation in the Rat Colon. Carcinogenesis, 1993; 14: 2219-25.
  9. Rao, C.V. et al: (1993) Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound Cancer Res. 55,259-266
  10. Sharma, S.C. et al: Lipid Peroxide Formation in Experimental Inflammation. Pharmacol. 1972; 21: 1210-1214.
  11. Sharma, O.P. (1976). Antioxidant activity of curcumin and related compounds Pharmacol. 25,1811-1812.

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CENTAMIN FORTE tabletta és szirup (1)
CENTAMIN FORTE syrup
5250 Ft