IMMUNORM tablet

Leírás

Each tablet contains:

Active substances:

Extracts of:

Other ingredients

Lubricants:  Ethyl cellulose, Polyvinyl pyrrolidone k30, Starch, Sodium starch glycolate, Magnesium Sulphate, Talc.

Coating material: Hydroxy propyl methyl cellulose, Titanium dioxide, talc, PEG – 600, Oxide yellow, Isopropyl alcohol, Methylene dichloride.

Preservatives: Methylparaben Sodium and Propylparaben Sodium

Tinospora cardifolia:

Pharmacology:

Protective effect:

It has been reported to increase leucocyte counts and ablate neutropenia following single and multiple doses of cyclophosphamide. Pre-treatment with Tinospora cordifolia has also been shown to afford protection against induced infections.

Immunomodulatory effect:

Tinospora cordifolia exerts its action by promoting leukocytosis with predominant effect on neutrophils. It enhances the phagocytic and intracellular killing capacity of macrophages and PMNs (Polymorphonuclear leukocytes), stimulates the release of cytokines such as GM-CSF (Granulocyte Macrophage- Colony Stimulating Factor), IL1, IL2 and causes the proliferation of B-lymphocytes.

The treatment with Tinospora cordifolia for 15 days induced leukocytosis with predominant neutrophilia with a statistically significant (p < 0.001) increase of 82%. Similarly, the absolute neutrophil count in the Tinospora cordifolia treated group was significantly (p < 0.001) more than in the control group.

Aloe vera:

Pharmacology:

Immunomodulatory effect: Extracts of Aloe vera have been claimed to have several important therapeutic properties including acceleration of wound healing, immune stimulation, anti-cancer, and anti-viral effects. However, the biological mechanisms of these activities are unclear.

Because of this wide diversity of effects, it is believed that they may be exerted through pluripotent effector cells such as macrophages. It was found to stimulate macrophage cytokine production, nitric oxide release, surface molecule expression, and cell morphologic changes. The production of the cytokines IL-6 and TNF-alpha were dependent on the dose of extracts of Aloe vera provided. Nitric oxide production, cell morphologic changes and surface antigen expression were increased in response to stimulation by a mixture of aloe vera extracts and IFN-gamma.

Exposure of macrophages to aloe vera extract upregulates the RB (Respiratory Burst), phagocytosis and candicidal activity.

When peritoneal macrophages were exposed to extract from Aloe vera, there was approximately a two-fold increase in RB (Respiratory Burst), a marked increase in phagocytosis (45%) and killing of Candida albicans (38%). When incubated with Aloe vera extract, 98% of yeas cell were killed.

Anti-leukemic effect: When the pharmacological effect of diethyl-hexyl-phthalate (DEHP) from Aloe vera Linne, was investigated on the apoptosis of human leukemic cell lines K562, HL60 and U937, the following results were obtained: At a level of 10 microg mL(-1) DEHP a significant anti-leukemic effect was observed for all three cell lines, as measured by clonogenic assay. After treatment with 10 microg mL(-1) DEHP for 4 h, agarose gel electrophoresis and flow cytometric analysis confirmed the occurrence of apoptosis. These results indicate that DEHP isolated from Aloe vera Linne has a potent antileukemic effect, and thus represents a new type of pharmacological activity with respect to human leukemic cells.

Curcumin Longa:

Immunomodulatory effect:

The immunomodulatory effect of Curcuma longa extract on various aspects of immune response is well established, including its effect on lymphoid cell population, Antigen presentation, humoral and cell mediated immunity and cytokine production.

Ocimum sanctum:

Immunomodulatory effect:

Studies with alcoholic extracts of Ocimum sanctum have shown that it improves and modulates immunity.

Registration number: 1708/1/NM/2020 NÉBIH ÁTI (60 tabl)

1. Thatte UM, Dahanukar SA. Immunotherapeutic Modification of Experimental Infections by Indian Medicinal Plants. Phyother Res 1989; 3: 43-49.
2. Thatte UM et al: Protective Effects of Indian Medicina Plants against Cyclophosphamide Neutropenia. J Postgrad Med 1987; 33: 185-188
3. Thatte UM, Dahanukar SA. Comparative Study of Immunomodulating Activity of Indian Medicinal Plants, Lithiumcarbonate and Glucan. Methods and Findings ExptClin Pharmacol 1988; 10: 639-644.
4. Thatte UM, Kulkarni MR, Dahanukar SA: Immunotherapeutic Modification of Escherichia coli Peritonitis and Bacteremia by Tinospore cordifolia. J Postgrad Med 1992; 38: 13
5. Dahanukar SA et al: Immunotherapeutic Modification by Tinospora cordifolia of Abdominal Sepsis Induced by Caecal Ligation in Rats. Indian J Gastroenterol 1988; 7: 21-23.
6. Burgess AW, Wilson EC, Metcalf D. Stimulation by Human Placental Conditioned Medium of Hematopoietic Colony Forming Human Marrow Cells. Blood 1977; 49: 573-576.
7. Zhang L, Tizard IR: Activation of a Mouse Macrophage Cell Line by Acemannan: The Major Carbohydrate Fraction From Aloe Vera Gel. 1996; 35(2): 119-28.
8. Stuart RW et al: Upregulation of Phagocytosis and Candidicidal Activity of Marcophages Exposed to the Immunostimulant Acemannan. Int J Immunopharmacol. 1997; 19(2): 75-82.
9. Lee KH, Hong HS, Lee CH, Kim CH: Induction of Apoptosis in Human Leukemia Cell Lines K562, HL60 and U937 by Diethylhexylphtalate Isolated from Aloe Vera Linne. J Pharm Pharmacol. 2000; 52(8): 1037-41.
10. Lissoni P et al: Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus aloe vera in untreatable advanced solid neoplasms Nat Immun. 1998; 16(1): 27-33.