STEATONIL tablet

Leírás

Each tablet contains:

Active substances:

Extracts of:

Other ingredients

Lubricants:  Ethyl cellulose, Polyvinyl pyrrolidone k30, Starch, Sodium starch glycolate  Magnesium Sulphate, Talc.

Coating material: Hydroxy propyl methyl cellulose, Titanium dioxide, talc, PEG – 600, Sunset yellow (E110), Isopropyl alcohol, Methylene dichloride.

Preservatives: Methylparaben Sodium and Propylparaben Sodium

Phyllanthusniruri

The extracts of Phyllanthus niruri have been thoroughly studied and documented for their hepatoprotective activity, detoxifying ability, and ability to protect against liver cirrhosis. Phyllanthus niruri exhibited hepato-protective property against cirrhosis by normalizing R.O.S. production and regulated expression of TGF beta, Colla 1, MMP2 and TMP 1 genes. Phyllanthus niruri extract could normalize increased levels of alkaline phosphatase in case of nimesulide-induced hepatotoxicity. The histopathological analysis also confirmed the protective effect of Phyllanthus niruri in severe fibrosis. Phyllanthus niruri made a drop in lipid peroxidation, enhanced antioxidant status and thereby prevented the damage to the liver and leakage of GGT and ALP enzymes.

The administration of Phyllanthus niruri extract has caused a significant increase in the Serum glucose, calcium and inorganic phosphorous levels and reduction in the serum triglyceride level whereas the milk yield was significantly increased. Negative Rothers’s and diastix strip test also indicated significant improvement in ketosis 1.

Grape Seed Extract

Analysis of hepatic transcript profile in cows fed with grape seed extract during the transition period at one week post partum indicates that polyphenol-rich feed components are able to inhibit ER stress-induced UPR and inflammatory processes both of which are considered to contribute to liver associated diseases and to impair milk performance in dairy cows, in the liver of dairy cows during early lactation.

Plasma concentration of the positive Acute Phase Protein (APP), Bovine Hepatoglobin (HP) and Serum Amyloid-A (SAA) were decreased in cows fed with Grape Seed Extract.

Feeding of Grape Seed Extract to dairy cows from 3 weeks anti-partum to 9 weeks post-partum causes beneficial changes in mRNA concentrations of hepatic genes, such as mRNA concentration of FGF21, an indicator of metabolic and Endoplasmic Reticulum (ER) stress 2.

Picrorhiza kurroa

Picrorhiza kurroa extract has the ability to increase bile production and showed a significant hypocholesterolemic effect and can, therefore, increase the HDL-level and reduce the triglyceride level significantly.

The elevation of transaminase reflects the necrosis of hepatocytes. ALT (Alanine Amino Transferase) in particular is the more specific index of hepatic necrosis. With a high-fat diet, Picrorhiza kurroa was more effective in bringing down ALT to a normal level.

Picrorhiza kurroa inhibits inflammatory TNF-receptor 1 and cyclooxygenase-2 in peritoneal macrophages. Treatment with Picrorhiza kurroa significantly inhibits iNOS and suppresses the activation of NF-kB through inhibition of its phosphorylation macrophages.

Steatonil prevents fat deposits on hepatocytes, protects hepatocytes from mitochondrial damage and improves feed intake and milk production.

It can effectively reduce ketosis and a negative energy balance during the transition phase – before and after parturition.

Registration number: 1710/1/NM/2020 NÉBIH ÁTI (60 tabl)

1. Gessner et al. BMC Genomics (2017) 18:253.
2. Verma PC, Basu V et al Curr Pharm Biotechnol 2009, Sept.
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