THROMBUP syrup

Leírás

Each 10 ml contains:

Active substances:

Extracts of:

Other ingredients

Color: Carmoisine  (EC 222-657-4)

Preservatives: Methyl-paraben Sodium and Propyl-paraben Sodium

Flavor: Blackcurrant

Carica papaya leaf extract: Carica papaya leaf extract increases the platelet count by strengthening bone marrow cells and preventing peripheral destruction of thrombocytes.

Carica papaya leaf extract administration improves bone marrow function and increases the glutathione level. It helps to increase the level of all blood cell precursors, particularly the megakaryocytes and the myeloblasts series, which results in the increase of the platelets and white blood cells within 72 hours. Also, as it has an erythrocyte membrane stabilizing effect, it markedly inhibits the hypo-tonicity-induced erythrocyte hemolysis.

Safety: Carica papaya leaf is nontoxic. L.D. 50 is ˃ 15 g/kg of body weight.

Tinospora cardifolia: As an immune modulator, it promotes leukocytosis with a predominant effect on neutrophils. It enhances the phagocytic and intracellular killing of macrophages and polymorphonuclear cells (PMNs). It stimulates the release of cytokines such as IL1 and IL2 and causes the proliferation of β-lymphocytes.

Andrographys paniculata: Andrographis paniculata has been effectively used in traditional Asian medicines for centuries and has been reported as having antibacterial, antifungal, antiviral, choleretic, hypoglycemic, hypocholesterolemic, adaptogenic, hepato-stimulant and hepatoprotective effects. Andrographis paniculata or its constituents have also been used to treat cases of leptospirosis, pulmonary tuberculosis (especially the exudative type), tuberculosis meningitis, and acute pyelonephritis. In acute pyelonephritis, the results were reported to be similar to those obtained with nitrofurantoin, but with fewer adverse effects. A primary modern use of A. paniculata is for the prevention and treatment of the infections of the upper respiratory tract.

Dogs with acute and chronic bleeding responded well, clinically, in terms of activity, appetite and the progressive reduction in bleeding signs to the oral administration of Thrombup.

A significant increase in the platelet count from day two was observed.

Oral therapy with Thrombup proved to reduce mortalities in dogs suffering from thrombocytopenia.

Registration number: 1711/1/NM/2020 NÉBIH ÁTI (200 ml)

1. Fenny Yunita et al: The Effects of Carica Papaya L. Leaves Extract Capsules on Platelets Count and Hematokrit Level in Dengue Fever Patient. Intl J Med Arom Plants 2012 2(4): 573-8.
2. Swati Patil et al.: Evaluation of Platelet Augmentation Activity of Carica papaya
   Leaf Aqueous Extract in Rats. J Pharmacog and Phytochem 2013 5: 57-60.
3. Soobitha Subendhran et al: Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever. Evidence based compl Alt Med 2013 1-7.
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   of Lead Acetate on Haemopoiesis and Aplasia and the Ameliorating Role of Carica Papaya Exper and Ther Med 2013 5: 648-52.
5. Achini Gammulle et al: Thrombocytosis and Anti-inflammatory Properties, and Toxicological Evaluation of Carica papaya Mature Leaf Concentrate in a Murine Model. Online Intl J Med PlantRes 2012 1(2): 21-30.
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7. Shahid Akbar: Andrographis paniculata: A Review of Pharmacological Activities and Clinical Effects. Alternative Medicine Review Volume 2011 16(1): 66-77.
8. Leon IC Tang et al: Screening of anti-dengue activity in methanolic extracts of medicinal plants BMC Complement Altern Med. 2012; 12: 3. 1-10.
9. G.R.Baranidharan et al.: Clinical Trials on the Efficacy of Thrombup (containing extracts of Carica Papaya Leaf and Tinospora Cordiofolia) in dogs with Thrombocytopenia. Study conducted at Madras Veterinary college. India 2015-16. 1-19.